UMBC Shady Grove Campus, 9636 Gudelsky Dr #4101, Rockville, MD 20850
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Location: Cambridge, Massachusetts
Type: Full Time
Preferred Education: Masters
Fermentation / Cell Culture
LifeMine Therapeutics, Inc. is the first biotechnology company exploiting the unique ability of fungi to produce powerful drugs optimized through billions of years of evolution, and deploying these molecules for the treatment of intractable human diseases via novel biological mechanisms. The company is using a genome mining and recombinant overexpression approach to mount a massive search for novel drugs through the fungal biosphere. With operations in Cambridge, Massachusetts, Gloucester, Massachusetts, and Basel, Switzerland, LifeMine brings a unique approach to its revolutionary scientific and medical mission.
We are seeking an experienced Fermentation Scientist or Engineer to execute robust and scalable fermentations using filamentous fungi for production of natural products in support of LifeMine’s genomically-enabled drug discovery platform.
Plan and conduct filamentous fungal fermentations using bioreactors at multiple scales
Establish and optimize seed train for various wild-type and genetically engineered fungal strains targeted for large-scale fermentation production
Identify and implement fermentation productivity improvements, scientific and engineering principles, as well as statistical process design and analysis
Apply current industry best practices, proactively evaluate new technologies, stay current with relevant literature, and implement new features and functionality in the bioprocess development platform
Engage in close, cross-functional collaborations with LifeMine’s Genomics, Strain Engineering, Microbiology, Natural Product Chemistry, and Bioinformatics groups to interpret data, reach conclusions, and make decisions
Ensure safe and axenic operation of all fermentation equipment
MS or PhD in chemical engineering or related field with 2+ years of experience in fermentation process development using microbes
Microbial fermentation expertise with bioreactors at multiple scales using non-conventional microbes. Filamentous fungal experience highly preferred
Knowledge of and hands-on experience with fermentation process design, optimization (DOE), and mixing/mass transfer
Working experience with statistical process design and analysis such as JMP and SpotFire
Ability to identify complex problems, review data to determine root cause, evaluate options and implement solutions
Demonstrated ability to work independently as well as in team environment, multitask and ensure flexibility in a dynamic environment required
Ability to lift 50 pounds
Ability to travel between our Gloucester and Cambridge locations
An understanding of Six Sigma and lean manufacturing principles preferred
LifeMine is an Equal Opportunity Employer and Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sexual orientation, gender identity, age, physical or mental disability, veteran status, genetic information, ethnicity, citizenship, or any other characteristic protected by law.
LifeMine Therapeutics is a biopharmaceutical company reinventing drug discovery by mining genetically-encoded small molecules (GEMs) from the biosphere. Through its evolutionarily-derived genomic drug discovery platform Avatar-Rx, LifeMine aims to bring unparalleled speed, predictability and scalability to drug discovery.
LifeMine has discovered, in genomic space, hundreds of potentially high-impact drug candidates relevant to targets across all major disease areas and has an initial focus on advancing highly impactful precision medicines in oncology and immune modulation.
LifeMine was founded in 2017 by renowned scientists and entrepreneurs, Gregory L. Verdine and Richard Klausner, and company-builder, WeiQing Zhou. With headquarters in Cambridge, MA, and operations in Gloucester, MA, LifeMine is opening its European Headquarters within Europe’s Biotechnology Hub of Basel, Switzerland.