Career Center

Summary of Position:
The Selmecki lab invites applications from candidates for a researcher 1 position. The
candidate will join a research team studying genome plasticity and drug resistance in
fungal pathogens (Candida species). We use evolutionary approaches to understand
the rate and dynamics in which mutations arise in fungal populations, in the presence
and absence of antifungal drugs. Additionally, we use comprehensive genomic
techniques, including Illumina and MinION whole genome sequencing, qPCR, ddPCR,
and CRISPr-Cas9 engineering to identify novel mechanisms of antifungal drug
resistance. We have identified genome rearrangements that cause drug resistance,
including novel chromosome structures, copy number variation, and recombination
hotspots. This candidate will help enable our ongoing research by performing various
molecular and cellular experiments and engaging in laboratory maintenance, ordering,
and support of a safe and secure workplace.
http://www.selmeckilab.com

Job Duties and Responsibilities:
Typical tasks (These examples do not include all possible tasks in this work and do not
limit the assignment of related tasks.)

• 75% Research and data analysis:
  • Individual will conduct complex, multi-step laboratory procedures based on written protocols or oral instruction from PI or other senior researchers, using molecular biological, microbiological, or genetic techniques on human fungal pathogens.
  • Individual will be expected to select and adapt methods to meet specific research needs and to assist in development of new laboratory techniques. Previous experience working in a microbiology laboratory and with fungi is recommended.
  • Individual must be able to learn and employ a wide variety of experimental techniques including but not limited to flow cytometry, DNA and RNA extractions, PCR, gel electrophoresis, tissue culture, transformation, Southern, and Western blot analyses.
  • Individual is expected to maintain a detailed notebook, tabulate and graph data, and interpret results on all procedures.
  • Individual will be expected to read relevant scientific literature as suggested by the investigation and to identify relevant facts, techniques, and procedures from the primary literature.
• 25% Laboratory Coordination:
  • Individual will be involved in the operation and maintenance of equipment, developing and implementing protocols, data management and analysis, ensuring lab safety, ordering, and assistance in the preparation of data for manuscripts and grants
  • Individual will work with other laboratory personnel to coordinate work schedules for execution of complex laboratory studies.

All required qualifications must be documented on application materials

Required Qualifications:

• Bachelor's degree in a biology-related field (Biology, Microbiology, Molecular Biology Biochemistry, etc.) or a combination of related STEM education and work experience to equal four years.
• Prior research experience in molecular biology or microbiology.
• Prior research experience with yeast (fungi) or pathogens.
• Ability to be part of a team as well as ability to work independently and follow established protocols with attention to detail.
• Ability to record, analyze, and troubleshoot problems independently.
• Strong organizational skills

Preferred Qualifications:

• Prior research experience with flow cytometry
• Prior experience with lab organization and coordination
• Strong oral and written communication skills
• Curiosity and desire to learn new skills
• Aptitude for bioinformatics