The Wang lab is in need of self-motivated postdoctoral fellow with a focus on development of novel antimicrobials to combat antibiotic-resistant pathogens. Currently, natural antimicrobial peptides registered in the antimicrobial peptide database (https://aps.unmc.edu) are utilized as templates. The postdoc fellow is anticipated to do innovative research, ranging from in silico, in vitro, to in vivo. For the in silico part, we use both 3D structure and database to guide the engineering of novel peptides into selective, stable and potent antibiotics. Antimicrobial activity and mechanisms of action of the newly designed peptides will be pursued in vitro by using different experiments. Both topical and systemic animal models are available for toxicity, efficacy and immune regulation studies. Candidates will previous knowledge and experience on peptides and murine models will be considered. The project is funded by the National Institutes of Health.
PhD or MD/PhD in microbiology, molecular biology, or related scientific field.
Expertise of efficacy evaluation of antimicrobial agents in mouse models.
A vital enterprise in the nation’s heartland, the University of Nebraska Medical Center has its eye on improving the future of health care in Nebraska and beyond. As Nebraska’s only public academic health sciences center, UNMC is committed to the education of a 21st century health care work force, to finding cures and treatments for devastating diseases, to providing the best care for patients, and to serving our state and its communities through award-winning outreach. UNMC also is committed to embracing the richness of diversity, and is a major economic engine for the state of Nebraska. Led by Chancellor Jeffrey P. Gold, M.D., UNMC has six colleges, two institutes and a graduate studies program, serving nearly 4,000 students in more than two dozen programs. Our physician assistant program was recently ranked ninth in the nation by U.S. News & World Report, and our primary care program was ranked 17. The university’s physical therapy, pharmacy and public health programs also are ranked among the top in the country.
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