Yale Center for Molecular Discovery (YCMD) is a Yale University core facility focused on high throughput assay design and screening in micro plate formats. We are seeking an experienced and motivated scientist to join our Biology group to support University researchers in their efforts for the earliest phases of drug discovery, and to contribute to the state-funded PITCH program efforts. The Biotechnology Associate is expected to provide strong intellectual and technical support under the general guidance of the YCMD Director of Biology. He/she is expected to perform screening and discovery using Yale's small molecule and siRNA collections, liquid handling instruments, readout technologies and database. Primary duties include design and optimization of biochemical and cell-based assays in a micro plate format, as well as execution and interpretation of high-throughput screens both independently and as part of the matrixed team. Broad knowledge and experience is highly desired as projects and applications are diverse. Actively participate in research design, implementation and daily operations of the lab. Simultaneously carry out multiple and diverse research projects, both independently and in collaboration with PITCH project leads and scientists. Coordinate resources including other team members' activities to achieve project goals. Help troubleshoot problem areas. Design experiments, develop methods, analyze results and adapt to high-throughput protocols. Conduct screening. Identify and apply relevant statistical methods to assess assay performance and identify and prioritize assay hits. Prepare summary reports. Recommend approaches for validation and follow-up. Document research progress daily on Center's electronic management system. Present weekly updates to screening team. Document results for discussion and reporting purposes. Set up, run and maintain sophisticated Center instrumentation. Investigate, diagnose and correct system malfunctions. Write Standard Operating Procedures. Expand and improve Center's infrastructure and capabilities by anticipating future needs. Evaluate new methods, work with vendors, participate in technology evaluation and improvement projects both individually and as part of the team. Prioritize areas for development. Develop solutions to research problems through library research and readings of scientific material. Attend scientific seminars and conferences. Contribute scientific data to grant proposals. Author/co-author manuscripts for publication. Serve as an expert resource in the professional development of Yale researchers by teaching specialized techniques and analysis methods commonly used in biotechnology and pharmaceutical companies. Develop and teach lectures and hands-on courses, co-teach annual YCMD nanocourses, mentor undergraduate interns.
Posting Position Title: Biotechnology Associate 2
University Job Title: Biotechnology Associate
Work Week: Standard (M-F equal number of hours per day)
Required Skill/ability 1: Ability to work both independently and as part of matrixed team to manage scientific projects and design and carry out experimental programs. Strong organizational skills, ability to multi-task and juggle multiple active projects.
Required Skill/ability 2: Deep knowledge of molecular biology, biochemistry and cell biology. Strong tissue culture experience and experience with biochemical assays using recombinant proteins. Experience with cell-based and biochemical assay development. Strong quantitative skills and experience using scientific software for data analysis and statistics.
Required Skill/ability 3: Excellent communication and interpersonal skills. Ability to interact favorably and professionally with a diverse group of scientists and entrepreneurs. Ability to learn new techniques and manage complex laboratory processes.
Required Skill/ability 4:
Required Skill/ability 5:
Preferred Education, Experience and Skills: MS in Biology, Biochemistry or other related discipline and 4 years experience in academia or industry (Pharmaceutical or Biotechnology company), or PhD and 2 years of equivalent experience. Experience with liquid handling and automation, and high-throughput screening. Working experience using computer-run instrumentation and using statistical methods to analyze large scale scientific experiments.
Required Licenses Or Certifications:
Master's Degree in chemistry, biology, biochemistry, or other related discipline and three years of experience or an equivalent combination of experience and education.
Yale University is an American private Ivy League research university located in New Haven, Connecticut. Founded in 1701 in the Colony of Connecticut, the university is the third-oldest institution of higher education in the United States.